Factor VII Deficiency

What is Factor VII Deficiency?

Factor VII (seven) deficiency is a disorder caused by a lack of a protein called factor VII in the blood. It leads to problems with blood clotting (coagulation).

 

What causes Factor VII Deficiency?

When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade. It involves special proteins called coagulation, or clotting, factors. You may have a higher chance of excess bleeding if one or more of these factors are missing or are not functioning like they should.

Factor VII is one such coagulation factor. Factor VII deficiency runs in families (inherited) and is very rare. Both parents must have the gene to pass the disorder on to their children. A family history of a bleeding disorder can be a risk factor.

Factor VII deficiency can also be due to another condition or use of certain medicines. This is called acquired factor VII deficiency. It can be caused by:

  • Low vitamin K (some babies are born with vitamin K deficiency)
  • Severe liver disease
  • Use of medicines that prevent clotting (anticoagulants such as warfarin)

What are the symptoms of Factor VII Deficiency?

Symptoms may include any of the following:

  • Bleeding from mucus membranes
  • Bleeding into joints
  • Bleeding into muscles
  • Bruising easily
  • Heavy menstrual bleeding
  • Nosebleeds that do not stop easily
  • Umbilical cord bleeding after birth

 

How is Factor VII Deficiency Diagnosed?

Tests that may be done include:

  • Partial thromboplastin time (PTT)
  • Plasma factor VII activity
  • Prothrombin time (PT)
  • Mixing study

 

How is Factor VII Deficiency treated?

Bleeding can be controlled by getting intravenous (IV) infusions of normal plasma, concentrates of factor VII, or genetically produced (recombinant) factor VII.

You will need frequent treatment during bleeding episodes because factor VII does not last for long inside the body. A form of factor VII called NovoSeven can also be used.

If you have factor VII deficiency due to a lack of vitamin K, you can take this vitamin by mouth, through injections under the skin, or through a vein (intravenously).

If you have this bleeding disorder, be sure to:

  • Tell your health care providers before you have any kind of procedure, including surgery and dental work.
  • Tell your family members because they may have the same disorder but do not know it yet.